Assay for bilirubin
US4069016A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Jan 14, 1977 |
| Grant date | Jan 17, 1978 |
| Priority date | — |
| Expiry date | Jan 14, 1997 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T436/146666
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A method for the determination of bilirubin in liquid samples, particularly biological liquid samples. An assay method, as well as an analytical element, is disclosed. In accord with the assay method there are contacted together a liquid sample containing bilirubin as analyte and an interactive composition containing a bilirubin-active complex, the complex comprising a diffusible, bilirubin-displaceable, detectable ligand bound to a carrier which can also bind bilirubin. As a result of a competitive binding-displacement interaction between bilirubin and the complex, bilirubin binds to the carrier and displaces detectable ligand which can be selectively detected and used to determine the presence or amount of bilirubin. Appropriate carriers and detectable ligands can be chosen on the basis of their first order binding constants.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.