N.sup.2 -Naphthalenesulfonyl-L-arginine derivatives, and the pharmaceutically acceptable acid addition salts thereof
US4069329A · kind A · utility
Assignees
Inventors
Key dates
| Filing date | Jan 19, 1977 |
| Grant date | Jan 17, 1978 |
| Priority date | — |
| Expiry date | Jan 19, 1997 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
N.sup.2 -naphthalenesulfonyl-L-arginine esters and amides having the formula ##STR1## or the acid addition salts thereof with a pharmaceutically acceptable acid, wherein R is selected from the class consisting of (1) alkoxy, alkenyloxy, cycloalkoxy and halogenated alkoxy, aralkyloxy, and alkoxy substituted with an alkoxy group; ##STR2## wherein R.sub.1 and R.sub.2 are members selected from the class consisting of hydrogen, alkyl, aryl, alkenyl and cycloalkyl, and aralkyl and cycloalkylalkyl, and substituted alkyl, said substituent being selected from the class consisting of alkoxy, alkoxycarbonyl, acyl, acyloxy, arylcarbamoyl and N,N-polymethylenecarbamoyl, and carboxy; and ##STR3## wherein Z is a divalent group containing up to 10 carbon atoms, which consists of more than one group selected from the class consisting of methylene, monosubstituted methylene; and disubstituted methylene, and which may further contain at least one member selected from the class consisting of oxy-O-, thio --S--, cycloalkylene, imino, alkyl-substituted imino, acyl-substituted imino, and phenylene, which may be arranged in any order and complete the ##STR4## ring together with the said methylene, monosub…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.