9-(5-O-Acyl-.beta.-D-arabinofuranosyl)adenine compounds
US4069382A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | May 17, 1976 |
| Grant date | Jan 17, 1978 |
| Priority date | — |
| Expiry date | May 17, 1996 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P31/12
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
9-(5-O-Acyl-.beta.-D-arabinofuranosyl)adenine compounds and their production by reacting 9-(.beta.-D-arabinofuranosyl)adenine with a reactive derivative of an alkanoic acid. The compounds are useful as antiviral agents. The compounds are water-soluble and lipophilic, thereby being adaptable to a wide variety of pharmaceutical formulations. The present invention relates to new organic compounds that are useful in pharmacological agents and to a method for their production. More particularly, the invention relates to new 9-(5-O-acyl-.beta.-D-arabinofuranosyl)-adenine compounds that are represented by the formula ##STR1## where R is a straight chain alkanoyl group having from 2 to 8 carbon atoms or a branched chain alkanoyl group having 4 to 5 carbon atoms. Examples of alkanoyl groups represented by R are acetyl, propionyl, butyryl, pentanoyl, hexanoyl, octanoyl, 3-methylbutyryl, and 2,2-dimethylpropionyl. In accordance with the invention, 9-(5-O-acyl-.beta.-D-arabinofuranosyl)adenine compounds having formula I are produced by reacting 9-(.beta.-D-arabinofuranosyl)adenine with an equivalent quantity of a reactive derivative of an alkanoic acid that can be represented by the formula RO…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.