Intermediates for polycyclic quinoid antibiotics
US4070382A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Nov 18, 1975 |
| Grant date | Jan 24, 1978 |
| Priority date | — |
| Expiry date | Nov 18, 1995 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C46/06
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
There is provided a novel method of synthesizing certain tetracyclic quinones. In particular, there is provided a novel route to the synthesis of (.+-.)-7-deoxydaunomycinone and analogs thereof, which includes the provision of novel tri- and tetracyclic quinone intermediates. The -7-deoxydaunomycinone derived from naturally occurring daunomycin is a known compound, which is itself an intermediate in the preparation of the clinically accepted anti-tumor antibiotics daunomycine and its derivative adriamycin.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.