7-.alpha. substituted imino 7-.beta. substituted thio cephalosporin derivatives
US4071682A · kind A · utility
4Cited by
5References
9Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 18, 1976 |
| Grant date | Jan 31, 1978 |
| Priority date | — |
| Expiry date | Mar 18, 1996 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D501/57
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
An improved, versatile method for producing 7-cephalosporin derivatives having a 7-alkylthio or 7-arylthio group which comprises treating a 7-substituted imino halide, imino ether or iminothio ether of 7-aminocephalosporanic acid, 7-amino-3-desacetoxycephalosporanic acid and the like with a thiolating agent in the presence of a base, to obtain the thio derivative. These products are particularly useful for conversion to 7.alpha.-alkylthio or 7.alpha.-arylthio-7-acylamino intermediates which are converted to lower alkoxy cephalosporin derivatives useful as antibacterial agents.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.