Precompacted-starch binder-disintegrant-filler material for direct compression tablets and dry dosage capsules
US4072535A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Sep 26, 1975 |
| Grant date | Feb 7, 1978 |
| Priority date | — |
| Expiry date | Sep 26, 1995 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC08J2303/02
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A free-flowing binder-disintegrant powder material consisting essentially of a precompacted-starch powder, especially adapted for use in direct compression tabletting machines to produce non-friable tablets having excellent disintegration properties. This precompacted-starch powder is also useful as a free-flowing filler for blending with dry powder ingredients in dry-dosage capsules. The precompacted-starch powder is obtained by subjecting an ungelatinized granular starch to physical compaction without supplementary thermal energy, but with sufficient mechanical energy input to obtain a precompacted-starch having birefringent granules and non-birefringent fragments of granules and some aggregates of granules and fragments, and then dried to a moisture content of 9-16% total weight basis. After precompacting, the starch is pulverized to form a free-flowing powder having a loose bulk density of 0.5 to about 0.7 grams per milliliter. The precompacted-starch powder is essentially free of +40 mesh particles, at least 90% of the particles are -80 mesh, at least about 10% is +270 mesh, and from about 30% to 90% is -270 mesh size on a total weight basis (U.S. Standard Sieve Series, A.S.T.…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.