"New 1-(2'-aroyl eth-1' yl) 2-(4""-acetamido piperazine-1"" yl methyl) benzimidazoles, their therapeutical applications and method for their preparation"
US4072682A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Dec 22, 1975 |
| Grant date | Feb 7, 1978 |
| Priority date | — |
| Expiry date | Dec 22, 1995 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D235/10
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Compounds of the formula ##STR1## where Ar is phenyl, substituted phenyl, .alpha.-furyl or .alpha.-thienyl, and PA0 R is NH.sub.2, NHR.sup.1 wherein R.sup.1 is alkyl or cycloalkyl, or NR.sub.1 R.sub.2 wherein R.sub.1 and R.sub.2 are alkyl or --N.sub.1 R.sub.1 R.sub.2 is piperidino, pyrrolidino, morpholino or hexamethyleneimino. The compounds are prepared by reacting the corresponding Ar-substituted chloromethylated benzimidazole with the corresponding R-substituted piperazine. The compounds possess gastric antisecretory, anti-ulcerous, spasmolytic, anti-cholinergic, anti-bronchoconstrictive, analgesic, anti-inflammatory, anti-hypertensive and diuretic properties.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.