3,4-Dihydrocarbostyril derivatives
US4072683A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Nov 10, 1975 |
| Grant date | Feb 7, 1978 |
| Priority date | — |
| Expiry date | Nov 10, 1995 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D215/26
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Novel (3'-alkylamino-2'-hydroxy)propoxy-3,4-dihydrocarbostyril derivatives having .beta.-adrenergic nerves blocking activity and hypotensive activity and useful as a remedy for angina pectoris, irregular pulse and hypertension, etc., represented by the formula, ##STR1## wherein R.sub.1 is hydrogen, C.sub.1 -C.sub.4 alkyl or aralkyl and R.sub.2 is C.sub.1 -C.sub.4 alkyl, are prepared by reacting a 3,4-dihydrocarbostyril derivative represented by the formula, ##STR2## wherein R.sub.1 is C.sub.1 -C.sub.4 alkyl or aralkyl, with an epihalogenohydrin represented by the formula, ##STR3## wherein X is halogen, reacting the resulting product with an alkylamine represented by the formula, EQU R.sub.2 -- NH.sub.2 wherein R.sub.2 is as defined above, and, if necessary, reducing the resulting product.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.