Process for the resolution of DL-6-chlorotryptophan
US4072691A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Apr 29, 1976 |
| Grant date | Feb 7, 1978 |
| Priority date | — |
| Expiry date | Apr 29, 1996 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D209/20
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Seed crystals of one optically active enantiomer of 6-chlorotryptophan methanesulfonate or 6-chlorotryptophan benzenesulfonate are added to a supersaturated solution of DL-6-chlorotryptophan methanesulfonate or DL-6-chlorotryptophan benzenesulfonate. Crystallization of the optically active enantiomer results. The crystals are recovered. Alternatively, crystals of the optically active enantiomer may be added to a hot solution of DL-6-chlorotryptophan methanesulfonate or DL-6-chlorotryptophan benzenesulfonate to produce a supersaturated solution. The solution is then cooled to crystallize out the optically active enantiomer. Optically active 6-chlorotryptophan is prepared by treating optically active 6-chlorotryptophan methanesulfonate or 6-chlorotryptophan benzenesulfonate with an alkaline agent or an ion exchange resin.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.