Certain as-triazino 4,3-a! 1,4!benzodiazepine-1,2-dione compounds
US4073784A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Mar 9, 1977 |
| Grant date | Feb 14, 1978 |
| Priority date | — |
| Expiry date | Mar 9, 1997 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D243/20
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Compounds of the formula V ##STR1## wherein R.sub.1 is hydrogen, alkyl of 1 to 3 carbon atoms, inclusive; ##STR2## in which n is 2 or 3; and X is hydrogen, fluoro or chloro; wherein R.sub.2 is hydrogen, methyl or ethyl; wherein R.sub.3 is hydrogen, fluoro, chloro, bromo, trifluoromethyl and nitro; and wherein Ar is phenyl, o-chlorophenyl, o-fluorophenyl, 2,6-difluorophenyl or 2-pyridyl are prepared by treating a hydrazino compound of the formula: ##STR3## WHEREIN Ar, R.sub.2 and R.sub.3 are defined as above with an alkyl oxalyl chloride and cyclizing the obtained products. Compound V, including the pharmacologically acceptable acid addition salt thereof, have sedative, anxiolytic and muscle-relaxing activity and can be used for the treatment of anxieties or muscle strains of mammals, including man.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.