Halo-substituted hydroxybenzyl-amines as secretolytic agents

US4073942A · kind A · utility

Assignee

• Boehringer Ingelheim GmbH · DE

Inventors

• Johannes Keck · Zell am Harmersbach, DE
• Sigfrid Puschmann
• Gerd Kruger
• Klaus Noll · Cologne, DE
• Matyas Leitold · Biberach, DE
• Helmut Pieper · Lohr am Main, DE

Key dates

• Filing date: Nov 25, 1975
• Grant date: Feb 14, 1978
• Expiry date: Nov 25, 1995

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K31/135
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of the formula ##STR1## wherein X is chlorine or bromine; PA1 R.sub.1 is hydrogen, chlorine or bromine; PA1 R.sub.2 is isopropyl; tert.butyl; tert.pentyl; mono-, di- or tri-hydroxy-substituted branched alkyl of 3 to 5 carbon atoms; cyclohexyl; or hydroxycyclohexyl; and PA1 R.sub.3 is alkyl of 1 to 4 carbon atoms or, when R.sub.2 is other than cyclohexyl, also hydrogen; And non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as their salts are useful as secretolytics, antitussives, anti-ulcerogenics and stimulants for the production of the surfactant or anti-atelectasis factor of the alveoli.