Apparatus and method for the pharmacological manipulation of the coagulation mechanism in blood and for signalling the event of blood coagulation
US4074971A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jan 16, 1976 |
| Grant date | Feb 21, 1978 |
| Priority date | — |
| Expiry date | Jan 16, 1996 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/4905
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
An apparatus and method for accelerating the coagulation of blood and the components thereof uses the injection of an additive and gas to trigger coagulation. The appartus is designed to include a disposable multi-cell pack for minimizing manual handling of the blood and for minimizing exposure thereof to foreign surfaces with each cell containing a specimen of blood disposed above, but separated from, a predetermined amount of additive by means of a releasable cap. The cell pack containing the multiplicity of cells is inserted over a corresponding multiplicity of gas injection nozzles which effect the release of the caps in each cell for injecting the additive and the gas into the blood. As the gas passes through the blood, bubbles that are continually formed in the space above the blood burst and blood transported therein refluxes back into the blood below until coagulation occurs. A first photocell detector determines whether bubbles are formed above the surface of the blood and generates a signal if no bubbles exist due to a gas flow failure. When the blood commences to coagulate, the blood transported in the bubbles becomes gel-like and the transported blood rather than reflux…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.