Novel synthetic undecapeptide and clinical assay
US4075194A · kind A · utility
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3Claims
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Key dates
| Filing date | Dec 9, 1976 |
| Grant date | Feb 21, 1978 |
| Priority date | — |
| Expiry date | Dec 9, 1996 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/815
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A novel synthetic peptide corresponding to the eleven amino acid residues of the NH.sub.2 -terminal portion in the sequence of carcinoembrionic antigen (CEA) has been synthesized and this was attached by means of a water-soluble carbodiimide reagent to multichain poly(DL)-alanine as well as to bovine serum albumin. The resulting macromolecular conjugates provoked rabbit anti- CEA(1-11) peptide antibodies and a novel assay was developed for ascertaining the presence of adenocarcinomas of the digestive tract, pancreas and breast, based on said novel compositions of matter.
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