Process for preparing a 3-exomethylenecepham sulfoxide from penicillin sulfoxides
US4075203A · kind A · utility
9Cited by
4References
19Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Jun 16, 1976 |
| Grant date | Feb 21, 1978 |
| Priority date | — |
| Expiry date | Jun 16, 1996 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D205/095
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A penicillin sulfoxide ester is reacted with an N-chloro halogenating agent at a temperature of from about 75.degree. C. to about 135.degree. C. and in the presence of an alkylene oxide and calcium oxide to produce a 2-chlorosulfinylazetidin-4-one intermediate. The intermediate, upon separation from the alkylene oxide, calcium oxide, and any conversion products of both the alkylene oxide and calcium oxide, can be treated with stannic chloride to produce a 3-exomethylenecepham sulfoxide.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.