Programmed thermal degradation-mass spectrometry analysis method facilitating identification of a biological specimen
US4075475A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | May 3, 1976 |
| Grant date | Feb 21, 1978 |
| Priority date | — |
| Expiry date | May 3, 1996 |
Classification
- Technology area (CPC H)Electricity
- CPC primaryH01J49/0472
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A method facilitating the rapid and objective classification and/or identification of an unknown biological specimen is disclosed. A physical sample of the specimen is controllably heated in accordance with a predetermined nonisothermal time dependent function causing the sample to undergo controlled thermal degradation and give off a characteristic time dependent sequence or evolution pattern of gaseous degradation components (molecular fragments). This sequence of gaseous degradation components is then directly passed into an ionization source and ionized to provide a respectively corresponding time dependent sequence of characteristic ions. These ions are then analyzed in a mass spectrometer and measured data is recorded representing the respective quantities of ions having particular masses being produced as a function of time or temperature. This recorded data for an unknown biological specimen is then correlated with analogous time or temperature dependent data earlier recorded for known biological specimen thereby facilitating the classification and/or identification of the unknown biological specimen. The method may be used to facilitate the classification and identificatio…
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