7.alpha.-Halogeno-3-oxo-1,4-pregnadiene-21,17.beta.-carbolactones and related compounds
US4079054A · kind A · utility
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2References
8Claims
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Key dates
| Filing date | Dec 22, 1976 |
| Grant date | Mar 14, 1978 |
| Priority date | — |
| Expiry date | Dec 22, 1996 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07J71/0005
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Described are 3-oxo-7.alpha.-halogeno-17.alpha.-1,4-pregnadiene-21,17.beta.-carbolactone s and compounds related thereto, i.e. 2',3'.alpha.-tetrahydrofuran-2'-spiro-17(7.alpha.-halogeno-1,4-androstadie ne-3-ones) and (17R)-spiro-[7.alpha.-halogeno-1,4-androstadiene-17,1'-cyclobutane]-3,2'-d iones, all of which are valuable as aldosterone antagonists. Also described are the corresponding 7.beta.-hydroxy derivatives useful as intermediates.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.