Process of performing cyclization reactions using benzyl or pyridylamino malonic acid derivatives
US4079058A · kind A · utility
52Cited by
1References
23Claims
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Key dates
| Filing date | Oct 1, 1976 |
| Grant date | Mar 14, 1978 |
| Priority date | — |
| Expiry date | Oct 1, 1996 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D215/56
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Process of producing a naphthyridine or quinoline compound of the formula: ##STR1## wherein R.sub.2, R.sub.3, R.sub.4, and R.sub.6 can be alkyl, and R.sub.1 is nitrogen or CH. The corresponding pyridyl- or phenylaminomethylenemalonic acid diester is cyclized to yield said compound and an alcohol. The malonic acid diester at below reaction temperature is added to a solvent, e.g., diphenyl benzene, at above reaction temperature in proportion so that the mixture attains reaction temperature. Good yields at high throughputs are achieved.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.