1-Substituted-4-(1,2-diphenylethyl)piperazine derivatives and compositions containing the same
US4080453A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Mar 2, 1976 |
| Grant date | Mar 21, 1978 |
| Priority date | — |
| Expiry date | Mar 2, 1996 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D295/096
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
1-Substituted-4-(1,2-diphenylethyl)piperazine derivatives of the formula: ##STR1## wherein X is 2- or 3-hydroxy, 2-methoxy, 3-methyl, 3-alkoxy having 1 to 4 carbon atoms, or 2- or 3-alkanoyloxy having 2 to 5 carbon atoms; R is allyl, 3-hydroxyisoamyl, 3-methyl-2-butenyl, 3-methyl-3-butenyl, propyl, an unsubstituted monocycloalkyl having 5 to 8 carbon atoms, 2-chlorophenyl, or a phenyl substituted by hydroxy or methoxy; with proviso that when X is a substituent at position 2, R is cyclohexyl and when X is 3-methyl, R is 2-methoxyphenyl or an unsubstituted monocycloalkyl having 6 to 8 carbon atoms, and their pharmaceutically acceptable salts, and the preparation thereof, and analgesic or antitussive compositions containing the same as the essentially active ingredient.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.