2-Amino-4-phenyl-2-imidazolines and salts thereof

US4080503A · kind A · utility

Assignee

• Boehringer Ingelheim GmbH · DE

Inventors

• Werner Kummer · Ingelheim am Rhein, DE
• Herbert Koppe · Ingelheim am Rhein, DE
• Helmut Stahle
• Walter Haarmann

Key dates

• Filing date: Jul 16, 1973
• Grant date: Mar 21, 1978
• Expiry date: Jul 16, 1993

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D233/48
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of the formula ##STR1## wherein R.sub.1 and R.sub.2, which may be identical to or different from each other, are each hydrogen, chlorine, bromine or alkyl of 1 to 3 carbon atoms, PA1 R.sub.3 is hydrogen, furfuryl, hydroxyethyl, .beta.-hydroxy-phenethyl, monochlorophenyl-ethyl, dichlorophenyl-ethyl, N-ethyl-piperidyl or --A--NR.sub.6 R.sub.7, PA1 where PA2 A is alkylene of 1 to 5 carbon atoms, and PA2 R.sub.6 and R.sub.7 are alkyl of 1 to 2 carbon atoms or, together with each other and the nitrogen atom to which they are attached, form a heterocycle selected from the group consisting of pyrrolidino, morpholino, piperazino or N'-dimethylphenyl-piperazino, PA1 R.sub.4 is hydrogen or, together with R.sub.3 and the nitrogen to which they are attached, forms a heterocycle selected from the group consisting of piperidino, morpholino, dimethyl-morpholino or N'-methyl-piperazino, PA1 R.sub.5 is hydrogen, alkyl of 1 to 3 carbon atoms, hydroxy-ethyl, diethylamino-ethyl or furfuryl, Provided, however, that R.sub.1 and R.sub.2 are other than both hydrogen or both alkyl at the same time and that R.sub.3 and R.sub.5 are other than both hydrogen at the same time, or a non-toxic, pharmaco…