Anti-androgen compounds
US4081458A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | May 26, 1977 |
| Grant date | Mar 28, 1978 |
| Priority date | — |
| Expiry date | May 26, 1997 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C49/623
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Compounds of the formula ##STR1## in which each R is hydrogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, hydroxy, cyano, or halo, and both R groups are identical and are symmetrically located; R.sub.1 is C.sub.1 -C.sub.3 alkyl and R.sub.2 is methyl, or R.sub.1 and R.sub.2 taken together are (CH.sub.2 --.sub.n in which n is an integer from 4 to 6; and (1) X.sub.c and X.sub.d are hydrogen, and the combination of X.sub.a and Y.sub.a and of X.sub.b and Y.sub.b each represents a double bond, subject to the limitation that, when R.sub.1 is C.sub.1 -C.sub.3 alkyl and is other than methyl, X.sub.c, X.sub.d, and R.sub.1 are all in an .alpha.-configuration; or (2) X.sub.a, X.sub.b, X.sub.c, X.sub.d, Y.sub.a, and Y.sub.b are hydrogen, subject to the limitation that both X.sub.c and X.sub.d are in an .alpha.-configuration, both X.sub.a and X.sub.b are in an .alpha.-configuration or in a .beta.-configuration, and, R.sub.1, when it is C.sub.1 -C.sub.3 alkyl, is in an .alpha.-configuration, are useful in inhibiting the action of androgens or are intermediates to such anti-androgen compounds.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.