.DELTA..sup.15 -Steroids and pharmaceutical compositions thereof

US4081537A · kind A · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Helmut Hofmeister · Berlin, DE
• Rudolf Wiechert · Berlin, DE
• Klaus Annen · Berlin, DE
• Henry Laurent
• Hermann Steinbeck · Berlin, DE

Key dates

• Filing date: Oct 4, 1976
• Grant date: Mar 28, 1978
• Expiry date: Oct 4, 1996

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07J51/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

.DELTA..sup.15 -Steroids of the formula ##STR1## wherein R.sub.1 is a hydrogen atom, trialkylsilyl or acyl; R.sub.2 is ethynyl, chloroethynyl or propinyl; and X is an oxygen atom, ##STR2## or NOR.sub.4 wherein R.sub.3 is a hydrogen atom or acyl and R.sub.4 is a hydrogen atom, acyl, alkyl or tetrahydropyranyl, possess progestational and ovulation and nidation inhibiting activities.