Pyrazol-5-ones

US4081596A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Eike Moller · Wuppertal, DE
• Karl Meng
• Egbert Wehinger
• Harald Horstmann

Key dates

• Filing date: Nov 19, 1975
• Grant date: Mar 28, 1978
• Expiry date: Nov 19, 1995

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D231/24
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

1-Substituted pyrazol-5-ones of the formula ##STR1## and pharmaceutically acceptable, nontoxic salts thereof, wherein R is hydrogen, amino, alkyl, alkenyl, phenyl or trifluoromethyl; PA1 R.sup.1 is hydrogen, alkyl, alkenyl, unsubstituted or substituted aryl or unsubstituted or substituted aralkyl; PA1 R.sup.2 is alkyl; and PA1 R.sup.3 is pyridyl, aryl or substituted by: PA2 A. 1 or 2 of the same or different substitutents selected from the group consisting of halogen, trifluoromethyl, lower alkyl, lower alkenyl and lower alkoxy; PA2 B. cycloalkyl of 5, 6 or 7 carbon atoms or cycloalkenyl of 5, 6 or 7 carbon atoms; PA2 C. mono(lower alkyl)amino, di(lower alkyl)amino, trifluoromethoxy, nitro, cyano, carbamoyl, lower alkylcarbamoyl, di(lower alkyl)carbamoyl, sulphamyl, lower alkylsulphamyl, di(lower alkyl)sulphamyl, or --SO.sub.n lower alkyl wherein n is 0, 1 or 2; PA2 D. a member selected from the group consisting of mono(lower alkyl)amino, di(lower alkyl)amino, trifluoromethyl, nitro, cyano, carbamoyl, lower alkylcarbamoyl, di(lower alkyl)carbamoyl, sulphamyl, lower alkylsulphamyl, di(lower alkyl) sulphamyl, and --SO.sub.n lower alkyl wherein n is 0, 1 or 2, and 1 or 2 of the same o…