Clottable fibrinogen free Factor VIII product and process
US4085095A · kind A · utility
23Cited by
2References
1Claims
0Family size
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Key dates
| Filing date | Dec 15, 1976 |
| Grant date | Apr 18, 1978 |
| Priority date | — |
| Expiry date | Dec 15, 1996 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/83
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Lyophilizable, clottable fibrinogen free, Factor VIII is produced on a commercial scale from a fibrinogen containing Factor VIII concentrate by sequentially, precipitating a major portion of the clottable fibrinogen by the addition of an ethylene oxide-polyoxypropylene block copolymer, clotting the remainder of the clottable fibrinogen by the addition of a small amount of a thrombin mimetic enzyme which does not decrease the potency of the Factor VIII, and adding human albumin to the resultant clottable fibrinogen free Factor VIII to stabilize its potency during lyophilization.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.