1,5-Dihydro-7-aryl-as-triazine[4,3,-.alpha.][1,4]benzodiazepin-1-ols
US4086230A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Mar 9, 1977 |
| Grant date | Apr 25, 1978 |
| Priority date | — |
| Expiry date | Mar 9, 1997 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D243/20
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Compounds of the formula: ##STR1## wherein R.sub.1 is alkyl of 1 to 3 carbon atoms, inclusive; wherein R.sub.2 is hydrogen, methyl or ethyl; wherein R.sub.3 is hydrogen, fluoro, chloro, bromo, nitro and -CF.sub.3 ; and wherein Ar is phenyl, o-chlorophenyl, o-fluorophenyl, 2,6-difluorophenyl, and 2-pyridyl, are prepared by treating a hydrazino compound of the formula: ##STR2## with a carbonyl compound II: ##STR3## wherein R.sub.1 is defined as above, and R', R" are alkyl of 1 to 3 carbon atoms, inclusive, or the group ##STR4## is a cyclic acetal, such as ##STR5## to give a compound of formula III: ##STR6## wherein R.sub.1, R.sub.2, R.sub.3, R', R" and Ar are defined as above, and cyclizing compound III to give the compound IV above. Compounds III and IV, including the pharmacologically acceptable acid addition salt of these compounds, have sedative, anxiolytic and muscle-relaxing activity and can be used for the treatment of anxieties or muscle strains of mammals, including man.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.