Cephalosporins and their production

US4086340A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Wilfried Schrock
• Hans-Bodo Konig
• Michael Preiss · Leinfelden, DE
• Karl G. Metzger · Wuppertal, DE
• Michael Walkowiak · Leverkusen, DE

Key dates

• Filing date: May 12, 1976
• Grant date: Apr 25, 1978
• Expiry date: May 12, 1996

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D501/20
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Cephalosporins of the formula ##STR1## their pharmaceutically-acceptable, nontoxic salts, and hydrates thereof are produced, wherein PA1 A is hydrogen; unsubstituted or substituted alkyl; aryl; or R.sub.1 --X--, wherein PA1 X is --CO-- or --SO.sub.2 --, and PA1 R.sub.1 is hydrogen, unsubstituted or substituted alkyl; aryl; thienyl; furyl; amino; alkylamino; dialkylamino; pyrrolidyl; or piperidyl; Or when PA1 X is --CO--, PA1 R.sub.1 can also be alkoxy; PA1 B is phenyl, methylphenyl, chlorophenyl, hydroxyphenyl or the moiety ##STR2## E is hydrogen, hydroxyl or acetoxy; and C is a center of chirality. These compounds are particularly useful for their antimicrobial and, particularly, antibacterial effects.