Preparation of melt-sprayed spherical phenacetin granules

US4086346A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Ernst Bocker
• Wolfgang Kracht
• Roland Rupp · Bensberg, DE
• Erhard Schellmann · Cologne, DE
• Viktor Trescher · Leverkusen, DE
• Martin Ullrich · Leverkusen, DE

Key dates

• Filing date: Sep 7, 1976
• Grant date: Apr 25, 1978
• Expiry date: Sep 7, 1996

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K9/2095
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Substantially spherical granules of phenacetin are prepared by spraying liquid phenacetin which has been melted without decomposition by means of rapid passage through a melting device in which superheating is minimized. The resultant melt-sprayed granules are superior to crystalline phenacetin in the formulation of pharmaceutical tablets.