Analgesically useful 2-tetrahydrofurfuryl-5-lower alkyl-2-oxy-6,7-benzomorphans and salts thereof

US4087532A · kind A · utility

Assignee

• Boehringer Ingelheim GmbH · DE

Inventors

• Herbert Merz · Ingelheim am Rhein, DE
• Adolf Langbein
• Gerhard Walther · Bingen, DE
• Klaus Stockhaus

Key dates

• Filing date: Apr 2, 1976
• Grant date: May 2, 1978
• Expiry date: Apr 2, 1996

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D221/26
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of the formula ##STR1## wherein R.sub.1 is methyl, ethyl or propyl, PA1 R.sub.2 is hydrogen, methyl or ethyl, PA1 R.sub.3 is hydrogen or methyl, and PA1 R.sub.4 is hydrogen, alkyl of 1 to 4 carbon atoms or alkanoyl of 2 to 5 carbon atoms, And non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as the salts are useful as analgesics.