Pharmaceutically active derivatives of 1-phenoxy-3-amino-propan-2-ol

US4088764A · kind A · utility

Assignee

• Cassella Farbwerke Mainkur Aktiengesellschaft

Inventors

• Thomas Raabe
• Otto Grawinger · Frankfurt am Main, DE
• Josef Scholtholt · Hanau, DE
• Rolf-Eberhard Nitz · Frankfurt am Main, DE
• Eckhard Schraven · Frankfurt am Main, DE

Key dates

• Filing date: Dec 10, 1974
• Grant date: May 9, 1978
• Expiry date: Dec 10, 1994

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D333/22
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to new pharmacologically valuable derivatives of 1-phenoxy-3-amino-propan-2-ol having the formula ##STR1## Wherein A denotes -CH.sub.2 -alkoxy, -O-alkoxyalkyl, -O-hydroxyalkyl, or ##STR2## R.sub.1 denotes hydrogen or methyl, Het denotes the radical of a pyrrole, pyrazole, imidazole, furane, thiophene, thiazole, pyridine, pyridazine, pyrimidine or pyrazine, which can additionally be substituted by one or more methyl groups, said radical is linked through a C atom, and R.sub.2 and R.sub.3 denote hydrogen, alkyl, alkenyl or cycloalkyl or conjointly with the N atom to which they are linked, and optionally with a further oxygen or sulfur hetero-atom, denote a saturated, 5-membered or 6-membered, monocyclic, heterocyclic structure, and alkyl radicals contain 1 to 4 carbon atoms, alkoxy radicals contain 1 to 4 carbon atoms, alkenyl radicals contain 3 or 4 carbon atoms and cycloalkyl radicals contain 5 to 7 carbon atoms; and aldehyde condensation products and acid addition salts thereof.