1-Lower alkyl-4,5-dihydro-5-phenyl-2-lower alkoxy carbonylaminoimidazoles and substituted phenyl derivatives thereof

US4088771A · kind A · utility

Assignee

• Syntex (U.S.A.) LLC · US

Inventors

• Adolph P. Roszkowski · Saratoga, US
• Colin C. Beard · Saratoga, US
• Charles Alois Dvorak · Palo Alto, US
• Klaus Weinhardt · San Francisco, US

Key dates

• Filing date: Jul 26, 1976
• Grant date: May 9, 1978
• Expiry date: Jul 26, 1996

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D233/48
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

1-Lower alkyl-4,5-dihydro-5-phenyl-2-lower alkoxycarbonylaminoimidazoles, and substituted phenyl derivatives thereof, and pharmaceutically acceptable salts thereof, and methods of preparing such compounds. In one method, the compounds can be prepared by treating the corresponding .beta.-lower alkylamino-.beta.-(phenyl or substituted phenyl)-ethylamine with the desired 1,3-bis (alkoxycarbonyl)-S-methylisothiourea or 1-alkoxycarbonyl-S-methylisothiourea. The compounds can also be prepared by treating the corresponding 1-lower alkyl-2-amino-4,5-dihydro-5-(phenyl or substituted phenyl)-imidazole with the desired dialkylcarbonate. The subject compounds are useful as psychotherapeutic agents in treating or palliating abnormal conditions, in mammals, which involve the central nervous system.