Patent · US Expired

Substituted phenylguanidines and processes for their preparation and use

US4088780A · kind A · utility

1Cited by

2References

20Claims

0Family size

Assignee

BAYER HEALTHCARE LLC · DE

Inventors

Heinrich Kolling · Haan, DE
Herbert Thomas
Arno Widdig · Odenthal, DE
Hartmund Wollweber · Wuppertal, DE

Key dates

Filing date	May 26, 1976
Grant date	May 9, 1978
Priority date	—
Expiry date	May 26, 1996

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61K31/155
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

N-[2-(Substituted amido)phenyl]-N',N"-bis-carbonylguanidines bearing an optionally substituted phenoxy, phenylthio, phenylsulfinyl or phenylsulfonyl group in the 4- or 5-position of the 2-(substituted amido)-phenyl group are anthelmintic agents. The compounds, of which N-(2-acetamido-4-phenylthiophenyl)-N',N"-bis-carbomethoxyguanidine is a typical example, are prepared through the reaction of isothiourea-S-alkyl ether and an appropriately substituted 2-aminoanilide.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.