Rapidly solubilized AHF composition and process for preparing same
US4089944A · kind A · utility
31Cited by
3References
36Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Oct 5, 1976 |
| Grant date | May 16, 1978 |
| Priority date | — |
| Expiry date | Oct 5, 1996 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/37
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The rate of solubility of a freeze-dried solid composition containing therapeutic amounts of anti-hemophilic factor (AHF) is greatly increased by carrying out the solubilization in the presence of at least a critical threshold amount of a water soluble carbohydrate. The carbohydrate is incorporated into the AHF composition in sufficient quantity to provide at least 2 weight units of carbohydrate (expressed in grams) per 100 volume units of AHF solution (expressed in milliliters). This enhanced rate of solubility permits rapid treatment of hemophilic patients.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.