Difluorosteroids and processes for their manufacture
US4092310A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jul 23, 1975 |
| Grant date | May 30, 1978 |
| Priority date | — |
| Expiry date | Jul 23, 1995 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07J7/0005
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A novel group of 18,18-difluorosteroids of the general formula ##STR1## wherein St, R.sub.1 and R.sub.2 have the meanings given hereinafter is produced by a chemically novel process characterized in that a corresponding 18-oxo compound is treated with a compound of the formula F.sub.3 SX, wherein X denotes a fluorine atom or an amino group derived from a secondary amine. The compounds of the invention are useful as pharmaceutical intermediates. A number of them are physiologically active and possess hormone-like properties, e.g. those of sexual and/or adrenocortical hormones, such as the gonadotropin-blocking, ovulation-blocking, androgenic, oestrogenic, progestagenic, anabolic, antioestrogenic, antiandrogenic, mineralocorticoid, glucocorticoid and antiinflammatory activity, and can be used in lieu of known hormones or agents possessing corresponding hormone-like properties.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.