Acyl-phenoxy-propanesulfoacids and salts, and artificial sweetening compositions containing the same
US4092346A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Dec 1, 1976 |
| Grant date | May 30, 1978 |
| Priority date | — |
| Expiry date | Dec 1, 1996 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA23L27/30
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Compounds of the formula (1), or their salts, ##STR1## are prepared as follows: (A) A COMPOUND OF THE FORMULA (II) ##STR2## is reduced; or (B) A COMPOUND OF THE FORMULA (III) ##STR3## is reacted, e.g. after protecting the phenolic hydroxy group attached to position 3 of the ring, with a compound of the formula (IV), ##STR4## or (C) GROUP R.sup.1 of a compound of the formula (V) ##STR5## is removed in an acidic medium, AND, IF DESIRED, THE COMPOUND OF THE FORMULA (I) is converted into salt, or a salt of a compound of the formula (I) is converted into the free acid or another salt thereof. The compounds of the formula (I) and their salts are valuable artificial sweetening agents. In the above formulae PA1 "alkyl" is a C.sub.1-4 alkyl group, PA1 R is hydrogen or a protecting group capable of splitting off upon hydrogenolysis, preferably benzyl or benzyloxycarbonyl, PA1 M+ is a proton or another cation, PA1 X is a group of the general formula O.sup.- M.sup.+, PA1 Y is halogen, or PA1 X and Y together represent an oxygen atom, and PA1 R.sup.1 is a protecting group capable of splitting off in acidic media, such as 2-tetrahydropyranyl or 1-ethoxyethyl.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.