Patent · US Expired

2,4-Dichloro-5-(.beta.-D-ribofuranosyl) pyrimidines and substituted derivatives

US4092472A · kind A · utility

3Cited by

1References

9Claims

0Family size

Assignee

University of Utah · US

Inventors

Leroy B. Townsend · Ann Arbor, US
Dean S. Wise · Salt Lake City, US
Robert A. Earl · Salt Lake City, US

Key dates

Filing date	Jul 30, 1976
Grant date	May 30, 1978
Priority date	—
Expiry date	Jul 30, 1996

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D405/04
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

A C-nucleoside compound, 2,4-dichloro-5-(2,3,5-Tri-O-acetyl-.beta.-D-Ribofuranosyl)pyrimidine, useful as a primary starting material in the synthesis of various C-nucleoside compounds having antitumor, antiviral and/or antibacterial activity. A structural formula is as follows: ##STR1## The location of the 2,4-dichloro members on the heterocycle, with the active sites of the carbohydrate being blocked, provides an intermediate compound well adapted for a variety of nucleophilic substitutions. Such procedures have yielded several novel analogs of known pyrimidine nucleosides found in RNA, as well as other compounds which have demonstrated chemotherapeutic utility.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.