Amino-benzoic acid amides

US4093734A · kind A · utility

Assignee

• Boehringer Ingelheim GmbH · DE

Inventors

• Gerd Kruger
• Johannes Keck · Zell am Harmersbach, DE
• Klaus Noll · Cologne, DE
• Helmut Pieper · Lohr am Main, DE
• Harald Ziegler
• Helmut Ballhause · Biberach, DE
• Joachim Kahling · Biberach, DE

Key dates

• Filing date: Oct 22, 1976
• Grant date: Jun 6, 1978
• Expiry date: Oct 22, 1996

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D453/02
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of the formula ##STR1## wherein (A) WHEN THE AMINO-SUBSTITUENT IS IN THE P-POSITION WITH RESPECT TO THE CARBONYL GROUP, PA2 R.sub.1 is chlorine in the o-position with respect to the carbonyl group, PA2 R.sub.2 is hydrogen, and PA2 R.sub.3 is ethylamino, cyclopentylamino, cyclohexylamino, cycloheptylamino, N-methyl-cyclohexylamino, benzylamino or 1-ethyl-pyrrolidyl-(2)-aminomethyl, or PA1 (b) when the amino-substituent is in the o--, m-- or p-position with respect to the carbonyl group, PA2 R.sub.1 is hydrogen, chlorine or bromine, PA2 R.sub.2 is trifluoromethyl, nitro or, when R.sub.4 is 1-(alkyl of 1 to 3 carbon atoms)-pyrrolidyl or 1-(alkyl of 1 to 3 carbon atoms)-piperidyl, also fluorine, chlorine, bromine or methyl, PA2 R.sub.3 is (alkyl of 1 to 5 carbon atoms)-amino, (cycloalkyl of 3 to 7 carbon atoms)-amino, benzylamino, quinuclidinyl-amino or --NH--(CH.sub.2).sub.n --R.sub.4 PA3 where R.sub.4 is pyridyl, 1-(alkyl of 1 to 3 carbon atoms)-pyrrolidyl, 1-(alkyl of 1 to 3 carbon atoms)-piperidyl or, when n is 2 or 3, also imidazolonyl, pyrrolidino, piperidino or morpholino, and PA3 n is 0, 1, 2 or 3, And non-toxic, pharmacologically acceptable acid addition salts thereo…