7.beta.-[2-Etherified oximino-2-(thienyl-, furyl- or pyridylacetamido)] cephalosporins
US4093803A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jan 26, 1977 |
| Grant date | Jun 6, 1978 |
| Priority date | — |
| Expiry date | Jan 26, 1997 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D499/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention provides novel antibiotic compounds which are 7.beta.-acylamidoceph-3-em-4-carboxylic acids, and non-toxic derivatives thereof characterized in that the acylamido group has the structure ##STR1## where R is a hydrogen atom or an organic group and R.sup.a is an etherifying monovalent organic group linked to the oxygen atom through a carbon atom. The compounds are syn isomers or exist as mixtures containing at least 75% of the syn isomer. These antibiotic compounds possess high antibacterial activity against a range of gram positive and gram negative organisms coupled with particularly high stability to .beta.-lactamases produced by various gram negative organisms. The invention is also concerned with the administration of the compounds.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.