Production of bis-(morpholino-N-alkyl) ethers
US4095022A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Apr 23, 1976 |
| Grant date | Jun 13, 1978 |
| Priority date | — |
| Expiry date | Apr 23, 1996 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC08G18/2081
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
An improved process is disclosed for selectively producing a bis-(morpholino-N-alkyl) ether directly from the corresponding N-(hydroxyalkyl)morpholine compound. The improved process includes contacting the N-(hydroxyalkyl)morpholine compound with a catalytically effective amount of a silica-alumina or certain phosphorus containing substances at a temperature of about 200.degree. C to 300.degree. C under a pressure sufficient to maintain the mixture substantially in liquid phase and recovering from the resultant reaction mixture the bis-(morpholino-N-alkyl) ether. According to the preferred embodiment, N-(2-hydroxyethyl)morpholine is heated in the presence of a catalytic amount of a silica-alumina catalyst having an alumina content of from about 5 to about 50 wt. % at temperatures of from about 240.degree. C to about 290.degree. C in liquid phase to selectively produce the corresponding N,N',2,2'-dimorpholinodiethyl ether (DMDEE).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.