Method for the chromatographic analysis of a technetium-containing mixture
US4095950A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Jun 11, 1976 |
| Grant date | Jun 20, 1978 |
| Priority date | — |
| Expiry date | Jun 11, 1996 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N30/90
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Method for the chromatographic analysis of a technetium-containing mixture of bound, reduced technetium; unbound, reduced technetium; and, free pertechnetate. A portion of the mixture is spotted on a chromatographic adsorbent, preferably cellulose-fiber paper, and is developed with an aqueous salt solution, preferably comprising sodium chloride and/or sodium pyrophosphate. The developed chromatogram has an isolated zone in which the unbound, reduced technetium is located. Simultaneously therewith, a second chromatogram is developed utilizing a suitable liquid organic solvent, preferably comprising a mixture of acetone and acetic acid. The developed chromatogram has an isolated zone in which the free pertechnetate is located. Radioactive measurements are made and the amounts of unbound, reduced technetium and of free pertechnetate are determined as proportions of total technetium. The amount of bound, reduced technetium may then be readily calculated. An elutable or chromatographic dye is preferably located on the adsorbent prior to development. The dye separates into colored regions which serve to indicate the completion of development, the approximate area of separation between th…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.