Process for making benzodiazepine derivatives

US4096141A · kind A · utility

Assignee

• Kali-Chemie Aktiengesellschaft · DE

Inventors

• Wolfgang Milkowski
• Renke Budden · Hannover, DE
• Siegfried Funke
• Rolf Huschens · Hannover, DE
• Hans Liepmann · Hannover, DE
• Werner Stuhmer
• Horst Zeugner

Key dates

• Filing date: May 12, 1976
• Grant date: Jun 20, 1978
• Expiry date: May 12, 1996

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D491/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A benzodiazepine derivative of the formula ##STR1## wherein R.sub.1 is hydrogen, lower alkyl which may be a straight chain, branched chain or cyclic group and may also be substituted, PA1 R.sub.2 is halogen, free hydroxyl, esterified hydroxyl, etherified hydroxyl, nitrile, carboxyl or a derivative thereof or is thioalkyl, thioaryl or the group ##STR2## R.sub.3 and R.sub.4 in this group being the same or different and being hydrogen, acyl, aryl, alkyl, aralkyl, aryloxyalkyl which latter five groups may also be substituted, or wherein R.sub.3 and R.sub.4 are saturated or unsaturated, straight chain or branched alkyl and in which groups the several alkyl may be interconnected directly or through a hetero atom, which if the hetero atom is nitrogen may also be substituted, and in which formula I, A and B are phenyl or phenyl, substituted by nitro, trifluoromethyl, halogen, methylthio, alkyl or alkoxy; or a pharmaceutically acceptable acid addition salt of said benzodiazepine derivatives of formula I.