Pyrazole derivatives

US4096152A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Eike Moller · Wuppertal, DE
• Karl Meng
• Egbert Wehinger
• Harald Horstmann

Key dates

• Filing date: Oct 6, 1975
• Grant date: Jun 20, 1978
• Expiry date: Oct 6, 1995

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D231/20
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Pyrazole derivatives of the formula: ##STR1## and pharmaceutically acceptable nontoxic salts thereof wherein R is hydrogen, trifluoromethyl or alkyl; PA1 R.sup.1 is hydrogen or alkyl; PA1 R.sup.2 is alkyl; PA1 R.sup.3 is mono- or di-substituted aryl, naphthyl, or pyridyl; PA1 R.sup.4 is R.sup.5 CO wherein R.sup.5 is alkyl unsubstituted or substituted by 1, 2 or 3 halogen moieties, by alkoxy, or by mono- or dialkylamino; lower alkoxy; dialkylamino; thiophene; phenyl unsubstituted or substituted by 1 or 2 alkyl, trifluoromethyl, alkoxy, nitro or halogen moieties; or a 5- to 7-membered heterocycle unsubstituted or substituted by 1 or 2 halogen, alkyl or nitro moieties; or PA1 R.sup.4 is Z--SO.sub.2 wherein Z is alkyl, phenyl or phenyl substituted by 1 or 2 alkyl, halogen, nitro, trifluoromethyl or trifluoromethylsulphonyl moieties; or dichloroquinoxalinyl. The pyrazole derivatives and their salts are useful as diuretics, saluretics and antihypertensives.