Inert core implant pellet

US4096239A · kind A · utility

Assignee

• Syntex LLC · PA

Inventors

• Martin Katz · Los Altos Hills, US
• John S. Kent · Palo Alto, US

Key dates

• Filing date: Oct 26, 1976
• Grant date: Jun 20, 1978
• Expiry date: Oct 26, 1996

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K9/1641
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A novel spherical implant pellet containing estradiol, estradiol benzoate, or mixtures thereof as the sole active ingredients which exhibits a substantially constant drug release rate over a timer period and substantially abrupt termination of drug release at the end of the time period is prepared which has an inert spherical core of a diameter of about 2-10 mm and a uniform coating of about 0.05-1 mm completely covering the core, the coating comprising about 5-99% suitable carrier and 1-95% drug. A drug may be administered at a constant rate over a chosen period by implanting the novel pellet and the release is substantially abruptly terminated at the end of said period without removing the pellet.