Immobilization of proteins with polyurethane polymers
US4098645A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Nov 18, 1976 |
| Grant date | Jul 4, 1978 |
| Priority date | — |
| Expiry date | Nov 18, 1996 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/816
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A protein which can be an enzyme is immobilized by: (a) admixing the protein and an isocyanate-capped liquid polyurethane prepolymer in the absence of water to form a resulting mixture (an intermediate product); and (b) forming the intermediate product by reacting it with water to form a polyurethane foam comprising the immobilized enzyme. When certain proteins in sufficient amount are mixed with the prepolymer in the absence of water the resultant protein prepolymer mixture will solidify to produce a solid non-foamed product containing a protein immobilized therein. Initially mixing the protein and prepolymer in the absence of water results in immobilization of a substantially greater amount of protein than when water is present.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.