4-Substituted pyrazoles

US4099011A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Eike Moller · Wuppertal, DE
• Karl Meng
• Egbert Wehinger
• Harald Horstmann
• Friedel Seuter

Key dates

• Filing date: Jun 8, 1976
• Grant date: Jul 4, 1978
• Expiry date: Jun 8, 1996

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D231/28
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Pyrazoles of the formula ##STR1## wherein R is hydrogen, alkyl, aryl, aralkyl, trifluoromethyl or a heterocycle; PA1 R.sup.1 is aryl or aralkyl unsubstituted or substituted by halo, trifluoromethyl, alkyl, alkoxy or nitro; or a halo-substituted alkylthio moiety; PA1 R.sup.2 is lower alkyl; phenyl; or benzyl; PA1 R.sup.3 is aryl unsubstituted or substituted by alkyl, alkenyl, alkoxy, halo, trifluoromethyl, trifluoromethoxy, mono- or di-alkylamino, nitro, cyano, carboxamido, sulphonamido or SO.sub.n -alkyl; phenyl having fused thereto a 5- to 7-membered isocyclic or heterocyclic ring, said heterocyclic ring having 1 or 2 oxygen or sulphur heteroatoms; or pyridyl; and PA1 R.sup.4 is unsubstituted or substituted carboacyl or sulphonyl; are useful for their diuretic, saluretic, antihypertensive and antithrombotic properties.