Method of detecting hepatitis B core antigen and antibody
US4100267A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Oct 1, 1975 |
| Grant date | Jul 11, 1978 |
| Priority date | — |
| Expiry date | Oct 1, 1995 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S436/82
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The formation of antibodies to the A-2 plaque virus previously propagated in tissue culture is described. The application describes an immune response against those antibodies and against the A-2 plaque virus antigen which is associated with human viral hepatitis both of type A and B origin. The reaction of antibody for A-2 plaque virus with the antigen from stool specimens of volunteers infected with type A hepatitis and from the sera of patients diagnosed as having type B hepatitis is described. Convalescent sera from both type A and type B hepatitis patients in reaction with the virus, demonstrate the presence of antigenic components in the plaque virus which react with human antibody formed in response to infection with either type A or type B hepatitis. Moreover, the A-2 plaque antibodies react with hepatitis B core antigen, while antibodies to HB.sub.c Ag react with A-2 plaque antigen. Additionally, methods for inducing antibody formation in humans from the A-2 plaque virus antigen are described, as are methods for detecting HB.sub.c Ag, HB.sub.c Ab, HAAg and HAAb.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.