Process for the cross-linking of proteins
US4101380A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 11, 1976 |
| Grant date | Jul 18, 1978 |
| Priority date | — |
| Expiry date | Jun 11, 1996 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/816
- WIPO fieldMacromolecular chemistry, polymers
- WIPO sectorChemistry
Abstract
The invention relates to a process for the cross-linking of proteins wherein the proteins to be cross-linked are reacted with a cross-linking agent selected from the group consisting of: (a) water soluble poly(ethylene oxide) derivatives of the general formula I EQU (z).sub.m --Y--(CH.sub.2 CH.sub.2 O).sub.n CH.sub.2 CH.sub.2 --Y--(Z).sub.m(I) wherein both n and m are at least 1; Y is a covalent bond or is an --R-- or --RO-- radical in which the oxygen is bound to the poly(ethylene oxide) and R is selected from the group consisting of methylene, ethylene, propylene, o--, m-- and p-phenylene, o--, m-- and p-phenylene carbamate optionally substituted by one or more alkyl, aryl, halo, nitro, oxo, carboxy, hydroxy, thio, sulfonate and phosphate groups; and Z is a reactive group selected from the groups consisting of halo-isocyanato-, isothiocyanato-, tosylate, acyl halides, acyl azides, aryl diazonium salts, acyl imidoester salts, activated esters of acyl residues and 2,4-dichlorotriazines; and (b) activated esters of di- and poly-carboxylic acids wherein the acids and the alcohol moieties thereof are water soluble.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.