Muramyldipeptide derivatives and process for the preparation thereof
US4101536A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 23, 1977 |
| Grant date | Jul 18, 1978 |
| Priority date | — |
| Expiry date | Jun 23, 1997 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K9/005
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Muramyldipeptide derivatives of the formula: ##STR1## wherein Y represents a mycoloyl group or a synthetic higher acyl group having total carbon number of C30-C90 and having at least a branched chain of long alkyl group on the .alpha.-position thereof, PA1 Q represents an -L-alanyl-D-isoglutamine group, a -glycyl-D-isoglutamine group or an -L-seryl-D-isoglutamine group; Salts of such derivatives; the method of preparing such derivatives and their salts; the derivatives and their salts having potent immunoadjuvant activities and antitumor activity and being applicable as the agent for the immunotherapy of cancer for humans and animals.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.