Aminobenzyl-amines and salts thereof

US4101671A · kind A · utility

Assignee

• Boehringer Ingelheim GmbH · DE

Inventors

• Johannes Keck · Zell am Harmersbach, DE
• Klaus Noll · Cologne, DE
• Helmut Pieper · Lohr am Main, DE
• Gerd Kruger
• Sigfrid Puschmann

Key dates

• Filing date: Mar 24, 1977
• Grant date: Jul 18, 1978
• Expiry date: Mar 24, 1997

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D221/24
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen or aliphatic or aromatic carboxylic acyl, PA1 R.sub.2 is hydrogen, chlorine or bromine, PA1 R.sub.3 is fluorine, alkyl of 1 to 4 carbon atoms, trifluoromethyl, cyano, carbamoyl, carboxyl, carbalkoxy, alkoxy, acetyl, 1-hydroxyethyl or ##STR2## where R.sub.6 and R.sub.7 are each alkyl, cycloalkyl, hydroxy-cycloalkyl or, together with each other and the nitrogen atom to which they are attached, pyrrolidino, piperidino or morpholino, and PA1 R.sub.4 and R.sub.5 are each hydrogen, alkyl of 1 to 5 carbon atoms, mono- or di-hydroxy (alkyl of 1 to 5 carbon atoms), alkenyl of 2 to 4 carbon atoms, cycloalkyl of 5 to 7 carbon atoms, mono- or di-hydroxy (cycloalkyl of 5 to 7 carbon atoms), benzyl, morpholinocarbonylmethyl or, together with each other and the nitrogen atom to which they are attached, pyrrolidino, piperidino, hexamethyleneimino, morpholino, N-methyl-piperazino or camphidino, Provided, however, that when R.sub.3 is carboxyl or carbalkoxy, R.sub.4 and R.sub.5 are other than hydrogen, alkyl, mono- or di-hydroxyalkyl, alkenyl, cycloalkyl, mono- or di-hydroxy-cycloalkyl or benzyl; and non-toxic, pharmacologically acceptabl…