Method of preparing hepatitis B core antigen
US4102996A · kind A · utility
15Cited by
0References
7Claims
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Inventors
Key dates
| Filing date | Apr 20, 1977 |
| Grant date | Jul 25, 1978 |
| Priority date | — |
| Expiry date | Apr 20, 1997 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S435/961
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
HB.sub.c Ag is prepared by isolating Dane particles by isopycnic banding of fluid from HB.sub.s Ag positive donors, optionally but preferably pelleting the Dane particles, and then removing the surface antigen by contacting the Dane particles with a nonionic surfactant having from about 15 to about 35 oxyethylene units in the presence of a reducing agent such as mercaptoethanol. The isolated core antigen is used as a diagnostic and immunologic agent.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.