Indolizine derivatives, pharmaceutical compositions and methods containing same

US4103012A · kind A · utility

Assignee

• Labaz · FR

Inventors

• Jean Gubin · Brussels, BE
• Gilbert Rosseels · Wemmel, BE

Key dates

• Filing date: Feb 16, 1977
• Grant date: Jul 25, 1978
• Expiry date: Feb 16, 1997

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D213/20
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Novel indolizine derivatives of the general formula: ##STR1## and pharmaceutically acceptable acid addition salts thereof, wherein R represents a branched- or straight-chain alkyl radical having from 1 to 5 carbon atoms, a phenyl radical, a mono-fluoro-, mono-chloro- or mono-bromo-phenyl, a di-fluoro-, di-chloro- or di-bromo-phenyl radical, a methoxy-phenyl radical or a methyl-phenyl radical optionally substituted on the aromatic moiety by an atom of fluorine, chlorine or bromine and R.sub.1 and R.sub.2, which are different, represent a hydrogen atom or a group of the formula: ##STR2## wherein R.sub.3 and R.sub.4 which are identical, each represent a hydrogen atom or a methyl radical, Am represents a dimethylamino, diethylamino, di-n-propylamino, di-n-butylamino, morpholino, piperidino, pyrrolidino or 4-methyl-piperazino group and n is an integer in the range of from 2 to 6 inclusive. They are effective for treating certain pathological or otherwise abnormal conditions of the heart and more particularly sinus tachycardia. Certain of them are also useful in the treatment of angina pectoris and cardiac arrhythmia.