Substituted 1-alkylthiophenyl-2,3,4,5-tetrahydro-1H-3-benzazepine compounds
US4104379A · kind A · utility
11Cited by
4References
16Claims
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Key dates
| Filing date | Jan 19, 1977 |
| Grant date | Aug 1, 1978 |
| Priority date | — |
| Expiry date | Jan 19, 1997 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C323/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A group of 1-phenyl-1H-3-benzazepines whose structures are characterized by having a functional thio containing group on the 1-phenyl moiety and which have pronounced peripheral and diminished central dopaminergic activity. This activity is manifested in an anti-hypertensive effect in humans. Particular species of this group include 6-chloro-7,8-dihydroxy-1-p-methylthiophenyl-2,3,4,5-tetrahydro-1H-3-benzaz epine and its derivatives which have dopaminergic activity.
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